Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
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چکیده
منابع مشابه
Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-cyclodextrin complex.
Mixtures containing ibuprofen (IB) complexed with β-cyclodextrin (βCD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, βCD and IBβCD) were characterized for moisture content, densities (true and bulk), angle of re...
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Gelatin-hydroxyapatite-polylactic acid (PLA) nanocomposites were synthesized using five different formulations. The nanocomposites were loaded with ibuprofen and the amount of drug in the carriers was determined. X-ray diffraction (XRD) analysis was conducted before and after drug loading to ensure the presence of ibuprofen on the nanocomposites. Drug delivery was evaluated in phosphate buffere...
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A novel application of whole cells of Nocardia corallina B-276 for the deracemisation of ibuprofen is reported. This microorganism successfully hydrolysed ibuprofen nitrile to ibuprofen amide, and ibuprofen amide to ibuprofen, using a suspension of cells in a potassium phosphate buffer solution (0.1 M, pH = 7.0). These results can be explained by the presence of NHase and amidase enzymes, but t...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2011
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2010.12.022